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Savvas Savvides

  • VIB Group leader since 2015
  • Professor of Structural Biology
  • Professor: Ghent Univ., Ghent, Belgium, since 2005
  • EMBO Research Fellow: Vrije Universiteit Brussel, Belgium, 2002-2004
  • Postdoc: Washington Univ. School of Medicine, USA, 2000-2002
  • PhD: Cornell Univ., USA, 2000

 

Research focus

We employ an integrative structural biology approach in conjunction with molecular interaction studies and cellular interrogation of the systems under study to elucidate the structural and mechanistic principles underlying the assembly, activation and pathophysiology of macromolecular complexes pivotal to inflammation, immunity, and cancer. The cornerstone of our research philosophy lies in a rigorous hypothesis-driven interrogation of the protein complexes under study, and is closely nested in collaborations with leading academic research groups in Belgium and abroad as well as industrial partners.

We currently focus on 3 main research topics:

  • Pro-inflammatory signaling complexes and antagonist design.
  • Extracellular assembly and activation principles of oncogenic receptor tyrosine kinases.
  • In vivo protein crystals in immunity, inflammation, and cancer

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